Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

Almost every death in young patients with an advanced skin tumor is caused by melanoma.
Today, with the help of modern treatments, these patients survive longer or can even …

Introduction: Due to its aggressiveness, cutaneous melanoma (CM) is responsible for most
skin cancer-related deaths worldwide. The origin of CM is closely linked to the appearance …

The melanoma transformation rate of an individual nevus is very low despite the detection of
oncogenic BRAF or NRAS mutations in 100% of nevi. Acquired melanocytic nevi do …

Acquired melanocytic nevi grow and persist in a stable form into adulthood. Using genome-
wide methylation profiling, we evaluated 32 histopathologically and dermoscopically …

Early detection of melanoma is critical to good patient outcomes, but we still know little about
the mechanisms of early melanoma development. Normal epidermis has many of the …

Acquired and congenital melanocytic naevi are common benign neoplasms. Understanding
their biology and genetics will help clinicians and pathologists correctly diagnose …

The results of the study by Tan et al. 1 in this issue of the British Journal of Dermatology
confirm that mutations in the mitogen-activated protein kinase (MAPK) pathway play a …

Introduction Having many melanocytic naevi or 'moles' on the skin is the strongest predictor
of melanoma; thus, much can be learnt from investigating naevi in the general population …

Precision prevention of advanced melanoma is fast becoming a realistic prospect, with
personalized, holistic risk stratification allowing patients to be directed to an appropriate …