Epigenetics is the epi-information beyond the DNA sequence that can be inherited from
parents to offspring. From years of studies, people have found that histone modifications …

Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …

Posttranslational modifications play key roles in regulating chromatin plasticity. Although
various chromatin-remodeling enzymes have been described that respond to specific …

Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …

How chromatin remodelers cooperate to organize nucleosomes around the start and end of
genes is not known. We determined the genome-wide binding of remodeler complexes …

Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Connections between perturbations that lie outside of our genome, that is, epigenetic
alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin …