Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Here, we introduce the 3D Genome Browser, http://3dgenome. org, which allows users to
conveniently explore both their own and over 300 publicly available chromatin interaction …

Contact map** experiments such as Hi-C explore how genomes fold in 3D. Here, we
introduce Juicebox. js, a cloud-based web application for exploring the resulting datasets …

Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …

The hierarchical organization of chromatin is known to associate with diverse cellular
functions; however, the precise mechanisms and the 3D structure remain to be determined …

In this exciting era of “next-gen cytogenetics”, the use of novel molecular methods such as
comparative genome hybridization and whole genome and whole exome sequencing …

This paper presents an interactive visualization interface-HiPiler-for the exploration and
visualization of regions-of-interest in large genome interaction matrices. Genome interaction …

Recent advances in next-generation sequencing (NGS) and chromosome conformation
capture (3C) analysis have led to the development of Hi-C, a genome-wide version of the 3C …

Current Hi-C analysis approaches are unable to account for reads that align to multiple
locations, and hence underestimate biological signal from repetitive regions of genomes …

The mammalian cell nucleus displays a remarkable spatial segregation of active
euchromatic from inactive heterochromatic genomic regions. In conventional nuclei …