Obesity, DNA damage, and development of obesity-related diseases

M Włodarczyk, G Nowicka - International journal of molecular sciences, 2019‏ - mdpi.com
Obesity has been recognized to increase the risk of such diseases as cardiovascular
diseases, diabetes, and cancer. It indicates that obesity can impact genome stability …

Translesion and repair DNA polymerases: diverse structure and mechanism

W Yang, Y Gao - Annual review of biochemistry, 2018‏ - annualreviews.org
The number of DNA polymerases identified in each organism has mushroomed in the past
two decades. Most newly found DNA polymerases specialize in translesion synthesis and …

Temozolomide: mechanisms of action, repair and resistance

J Zhang, M FG Stevens… - Current molecular …, 2012‏ - ingentaconnect.com
Glioblastoma multiforme is the most common aggressive adult primary tumour of the central
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …

Regulation of DNA repair throughout the cell cycle

D Branzei, M Foiani - Nature reviews Molecular cell biology, 2008‏ - nature.com
The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

N Kumar, AF Theil, V Roginskaya, Y Ali… - Nature …, 2022‏ - nature.com
UV-DDB, consisting of subunits DDB1 and DDB2, recognizes UV-induced photoproducts
during global genome nucleotide excision repair (GG-NER). We recently demonstrated a …

[HTML][HTML] A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids

SI Bukhari, M Manzoor, MK Dhar - Biomedicine & Pharmacotherapy, 2018‏ - Elsevier
Crocus sativus is an herbaceous plant that belongs to family Iridaceae. It is commonly
known as saffron and has been used for medicinal purposes since many centuries in India …

Principles of ubiquitin and SUMO modifications in DNA repair

S Bergink, S Jentsch - Nature, 2009‏ - nature.com
With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-
conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a …

How nucleotide excision repair protects against cancer

EC Friedberg - Nature Reviews Cancer, 2001‏ - nature.com
Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair
processes in humans, one type—nucleotide excision repair (NER)—specifically protects …

Nucleotide excision repair and human syndromes

J De Boer, JHJ Hoeijmakers - Carcinogenesis, 2000‏ - academic.oup.com
DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist
that safeguard the genome from these deleterious consequences. Nucleotide excision …

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans

MR Shen, IM Jones, H Mohrenweiser - Cancer research, 1998‏ - aacrjournals.org
The removal or repair of DNA damage has a key role in protecting the genome of the cell
from the insults of cancer-causing agents. This was originally demonstrated in individuals …