Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Silent brain infarcts: a systematic review

SE Vermeer, WT Longstreth, PJ Koudstaal - The Lancet Neurology, 2007 - thelancet.com
As the availability and quality of imaging techniques improve, doctors are identifying more
patients with no history of transient ischaemic attack or stroke in whom imaging shows brain …

Silent brain infarcts and the risk of dementia and cognitive decline

SE Vermeer, ND Prins, T den Heijer… - … England Journal of …, 2003 - Mass Medical Soc
Background Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI)
in healthy elderly people and may be associated with dementia and cognitive decline …

Homocysteine–from disease biomarker to disease prevention

AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Facts and recommendations about total homocysteine determinations: an expert opinion

H Refsum, AD Smith, PM Ueland, E Nexo… - Clinical …, 2004 - academic.oup.com
Background: Measurement of plasma total homocysteine has become common as new
methods have been introduced. A wide range of disorders are associated with increased …

Inflammation and cerebral small vessel disease: a systematic review

A Low, E Mak, JB Rowe, HS Markus, JT O'Brien - Ageing research reviews, 2019 - Elsevier
Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Homocysteine, B vitamins, and cognitive impairment

AD Smith, H Refsum - Annual review of nutrition, 2016 - annualreviews.org
Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study

SE Vermeer, M Hollander, EJ van Dijk, A Hofman… - Stroke, 2003 - Am Heart Assoc
Background and Purpose—Silent brain infarcts and white matter lesions are associated with
an increased risk of subsequent stroke in minor stroke patients. In healthy elderly people …

Exercise, brain, and cognition across the life span

MW Voss, LS Nagamatsu… - Journal of applied …, 2011 - journals.physiology.org
This is a brief review of current evidence for the relationships between physical activity and
exercise and the brain and cognition throughout the life span in non-pathological …

[HTML][HTML] Cerebral small vessel disease: a review focusing on pathophysiology, biomarkers, and machine learning strategies

E Cuadrado-Godia, P Dwivedi, S Sharma… - Journal of …, 2018 - ncbi.nlm.nih.gov
Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain
hemorrhages and is a leading cause of cognitive decline and functional loss in elderly …