Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
The mycobacterial cell envelope—a moving target
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …
Broad-spectrum anti-biofilm peptide that targets a cellular stress response
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
Macrophage: a cell with many faces and functions in tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
RETRACTED:(p) ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity
E Maisonneuve, M Castro-Camargo, K Gerdes - Cell, 2013 - cell.com
Persistence refers to the phenomenon in which isogenic populations of antibiotic-sensitive
bacteria produce rare cells that transiently become multidrug tolerant. Whether slow growth …
bacteria produce rare cells that transiently become multidrug tolerant. Whether slow growth …
M. tuberculosis persistence, latency, and drug tolerance
JE Gomez, JD McKinney - Tuberculosis, 2004 - Elsevier
The success of Mycobacterium tuberculosis as a pathogen is largely attributable to its ability
to persist in host tissues, where drugs that are rapidly bactericidal in vitro require prolonged …
to persist in host tissues, where drugs that are rapidly bactericidal in vitro require prolonged …
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
Understanding the physical characteristics of the local microenvironment in which
Mycobacterium tuberculosis resides is an important goal that may allow the targeting of …
Mycobacterium tuberculosis resides is an important goal that may allow the targeting of …
The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life
RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and
SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize …
SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize …
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action
The differential transcriptional response of Mycobacterium tuberculosis to drugs and growth-
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …