The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
Highly selective inhibition of tyrosine kinase 2 (TYK2) for the treatment of autoimmune diseases: discovery of the allosteric inhibitor BMS-986165
ST Wrobleski, R Moslin, S Lin, Y Zhang… - Journal of Medicinal …, 2019 - ACS Publications
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in
treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that …
treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that …
Glycolytic stimulation is not a requirement for M2 macrophage differentiation
Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages,
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …
whereas enhanced fatty acid oxidation and oxidative phosphorylation are the main …
The role of JAK/STAT pathway in fibrotic diseases: molecular and cellular mechanisms
J Liu, F Wang, F Luo - Biomolecules, 2023 - mdpi.com
There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …
Interferon gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity
Classical activation of M1 macrophages with lipopolysaccharide (LPS) is associated with a
metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability …
metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability …
[HTML][HTML] The regulation of JAKs in cytokine signaling and its breakdown in disease
The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
Prospects for pharmacological targeting of pseudokinases
Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
[HTML][HTML] Pathogenesis of myeloproliferative neoplasms
RC Skoda, A Duek, J Grisouard - Experimental hematology, 2015 - Elsevier
Major progress has been recently made in understanding the molecular pathogenesis of
myeloproliferative neoplasms (MPN). Mutations in one of four genes—JAK2, MPL, CALR …
myeloproliferative neoplasms (MPN). Mutations in one of four genes—JAK2, MPL, CALR …
Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases
A Hosseini, T Gharibi, F Marofi… - Journal of Cellular …, 2020 - Wiley Online Library
Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins
bind to receptors and signal their responses through Janus kinase (JAK) and signal …
bind to receptors and signal their responses through Janus kinase (JAK) and signal …