The Mycobactin biosynthesis pathway: A prospective therapeutic target in the battle against tuberculosis
The alarming rise in drug-resistant clinical cases of tuberculosis (TB) has necessitated the
rapid development of newer chemotherapeutic agents with novel mechanisms of action. The …
rapid development of newer chemotherapeutic agents with novel mechanisms of action. The …
Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery
G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …
3.08-Furans and their Benzo Derivatives: Applications
BA Keay, JM Hopkins, PW Dibble - … Heterocyclic Chemistry III, 2008 - hero.epa.gov
This chapter provides an overview of literature from 1996 on the applications of various
furan and benzofuran containing compounds. In addition to compounds that contain a furan …
furan and benzofuran containing compounds. In addition to compounds that contain a furan …
Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: Where we stand
Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …
Iron acquisition and metabolism as a promising target for antimicrobials (bottlenecks and opportunities): where do we stand?
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections
is one of the most crucial challenges currently faced by the scientific community …
is one of the most crucial challenges currently faced by the scientific community …
Synthesis and assessment of the in vitro and ex vivo activity of salicylate synthase (Mbti) inhibitors as new candidates for the treatment of mycobacterial infections
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most
dangerous infectious diseases worldwide. Because several pathogenic strains of M …
dangerous infectious diseases worldwide. Because several pathogenic strains of M …
Synthesis and In Vitro and In Vivo Biological Activity Evaluation and Quantitative Proteome Profiling of Oxadiazoles Bearing Flexible Heterocyclic Patterns
QQ Tao, LW Liu, PY Wang, QS Long… - Journal of agricultural …, 2019 - ACS Publications
A novel series of simple 1, 3, 4-oxadiazoles that bear flexible heterocyclic patterns was
prepared, and their biological activities in plant pathogenic bacteria, fungi, oomycetes, and …
prepared, and their biological activities in plant pathogenic bacteria, fungi, oomycetes, and …
Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors
G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …
infectious disease responsible as the most significant cause of mortality and morbidity …
Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo [3, 2-a][1, 3, 5] triazine derivatives
In response to the urgent need to encounter infection diseases, and upon increasing
concerns about the devastating effects of tuberculosis (TB), the promising thiazolidin-4-one …
concerns about the devastating effects of tuberculosis (TB), the promising thiazolidin-4-one …
Target identification in anti-tuberculosis drug discovery
R Capela, R Félix, M Clariano, D Nunes… - International Journal of …, 2023 - mdpi.com
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis (TB), a disease
that, although preventable and curable, remains a global epidemic due to the emergence of …
that, although preventable and curable, remains a global epidemic due to the emergence of …