Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?

M Tischer, G Pradel, K Ohlsen, U Holzgrabe - ChemMedChem, 2012 - Wiley Online Library
For more than 50 years dequalinium chloride has been used successfully as an antiseptic
drug and disinfectant, particularly for clinical purposes. Given the success of dequalinium …

Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development

M Schlitzer - ChemMedChem: Chemistry Enabling Drug …, 2007 - Wiley Online Library
Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Ecotoxicity analysis of cholinium-based ionic liquids to Vibrio fischeri marine bacteria

SPM Ventura, FA e Silva, AMM Gonçalves… - Ecotoxicology and …, 2014 - Elsevier
Cholinium-based ionic liquids are quaternary ammonium salts with a wide range of potential
industrial applications. Based on the fact that the cholinium is a complex B vitamin and …

Choline‐derivative‐based ionic liquids

J Pernak, A Syguda, I Mirska, A Pernak… - … A European Journal, 2007 - Wiley Online Library
A total of sixty‐three choline derivative‐based ionic liquids in the forms of chlorides,
acesulfamates, and bis (trifluoromethylsulfonyl) imides have been prepared and their …

Recent advances in antimalarial drug development

S Vangapandu, M Jain, K Kaur, P Patil… - Medicinal research …, 2007 - Wiley Online Library
Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence,
and drug resistance, is the most serious and widespread parasitic disease encountered by …

Synthesis of thiazolium-labeled 1, 3, 4-oxadiazole thioethers as prospective antimicrobials: In vitro and in vivo bioactivity and mechanism of action

MW Wang, HH Zhu, PY Wang, D Zeng… - Journal of agricultural …, 2019 - ACS Publications
In this study, a type of thiazolium-labeled 1, 3, 4-oxadiazole thioether bridged by diverse
alkyl chain lengths was constructed. The antimicrobial activity of the fabricated thioether …

Targeting the lipid metabolic pathways for the treatment of malaria

C Ben Mamoun, ST Prigge… - Drug development …, 2010 - Wiley Online Library
The control and eventual eradication of human malaria is considered one of the most
important global public health goals of the 21st Century. Malaria, caused by intraerythrocytic …

Recent updates in the discovery and development of novel antimalarial drug candidates

J Okombo, K Chibale - MedChemComm, 2018 - pubs.rsc.org
Though morbidity and mortality due to malaria have declined in the last 15 years, emerging
resistance to first-line artemisinin-based antimalarials, absence of efficacious vaccines and …

Recent highlights in antimalarial drug resistance and chemotherapy research

DA Fidock, RT Eastman, SA Ward, SR Meshnick - Trends in parasitology, 2008 - cell.com
This review summarizes recent investigations into antimalarial drug resistance and
chemotherapy, including reports of some of the many exciting talks and posters on this topic …

The regioselective synthesis of 2, 5-and 4, 5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino) ethanedithioates with isocyanides

KR Singh, C Santhosh, TR Swaroop… - Organic & Biomolecular …, 2022 - pubs.rsc.org
The regioselective synthesis of 2-(methylthio)-N-aryl/alkylthiazole-5-carboxamides and ethyl-
5-(aryl/alkyl carbamoyl) thiazole-4-carboxylates was carried out via the base-induced …