Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol

HY Peh, WSD Tan, W Liao, WSF Wong - Pharmacology & therapeutics, 2016 - Elsevier
The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in
reproduction. Today, there are eight naturally occurring vitamin E isoforms, namely α-, β-, γ …

Vitamin E and Alzheimer's disease: what do we know so far?

D Browne, B McGuinness, JV Woodside… - … interventions in aging, 2019 - Taylor & Francis
Vitamin E has been proposed as a potential clinical intervention for Alzheimer's disease
(AD) given the plausibility of its various biological functions in influencing the …

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

WG Wood, L Li, WE Müller… - Journal of …, 2014 - Wiley Online Library
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

The role of vitamin E in preventing and treating osteoarthritis–a review of the current evidence

KY Chin, S Ima-Nirwana - Frontiers in pharmacology, 2018 - frontiersin.org
Osteoarthritis is a debilitating disease of the joint involving cartilage degeneration and
chondrocytes apoptosis. Oxidative stress is one of the many proposed mechanisms …

The biological effects of tocotrienol on bone: A review on evidence from rodent models

KY Chin, S Ima-Nirwana - Drug design, development and therapy, 2015 - Taylor & Francis
Osteoporosis causes significant health care and economic burden to society, leading to a
relentless search for effective preventive agents. Tocotrienol, a member of the vitamin E …

Structural and biochemical perspectives in plant isoprenoid biosynthesis

S Kumari, P Priya, G Misra, G Yadav - Phytochemistry Reviews, 2013 - Springer
The isoprenoid family represents one of the most ancient and widespread classes of
structurally and functionally rich biomolecules known to man. Although these natural …

Tocotrienols for bone health: a translational approach

CL Shen, A Klein, KY Chin, H Mo, P Tsai… - Annals of the New …, 2017 - Wiley Online Library
Osteoporosis, a degenerative bone disease, is characterized by low bone mass and
microstructural deterioration of bone tissue resulting in aggravated bone fragility and …

[HTML][HTML] A review on the relationship between tocotrienol and Alzheimer disease

KY Chin, SS Tay - Nutrients, 2018 - mdpi.com
Alzheimer's disease (AD) is plaguing the aging population worldwide due to its tremendous
health care and socioeconomic burden. Current treatment of AD only offers symptomatic …

The role of tocotrienol in preventing male osteoporosis—A review of current evidence

KY Chin, S Ima-Nirwana - International journal of molecular sciences, 2019 - mdpi.com
Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a
higher mortality rate post-fracture than women and they are marginalized in osteoporosis …

Potential of tocotrienols in the prevention and therapy of Alzheimer's disease

W **a, H Mo - The Journal of nutritional biochemistry, 2016 - Elsevier
Currently there is no cure for Alzheimer's disease (AD); clinical trials are underway to reduce
amyloid generation and deposition, a neuropathological hallmark in brains of AD patients …