Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …

Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading
articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA …

Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with
significant burden on the individual and society. It is a severe disease for its high disability …

Background Curcumin has been shown to have chondroprotective potential in vitro.
However, its effect on disease and symptom modification in osteoarthritis (OA) is largely …

Osteoarthritis (OA) is the biggest unmet medical need among the many musculoskeletal
conditions and the most common form of arthritis. It is a major cause of disability and …

A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases
are secreted metalloproteinases that play key roles in the formation, homeostasis and …

Osteoarthritis (OA) is currently the most widespread musculoskeletal condition and primarily
affects weight-bearing joints such as the knees and hips. Importantly, knee OA remains a …

Osteoarthritis (OA) is a prevalent and severely debilitating disease with an unmet medical
need. In order to alleviate OA symptoms or prevent structural progression of OA, new drugs …