The complement system was defined over a century ago based on its ability to “complement”
the antibody-mediated and cell-mediated immune responses against pathogens. Today our …

The T-cell biology of the liver is unlike that of any other organ. The local lymphocyte
population is enriched in natural killer (NK) and NKT cells, which might have crucial roles in …

The complement system functions as an immune surveillance system that rapidly responds
to infection. Activation of the complement system by specific recognition pathways triggers a …

Being a major first line of immune defense, the complement system keeps a constant vigil
against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and …

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

Regulatory T (TR) cells consist of phenotypically and functionally distinct CD4+ and CD8+ T
cell subsets engaged both in maintaining self-tolerance and in preventing anti–non-self …

Several viruses are involved in the development of systemic vasculitides. Hepatitis C virus
(HCV) has been shown to be closely related to mixed cryoglobulinaemia, an immune …

Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory
pathways including the complement system and the kallikrein-kinin system (KKS) generating …

Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th
cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core …

It is believed that HCV can be acquired or transmitted via any blood-borne route. High-risk
settings include IDU and the transfusion of unscreened blood and blood products. Other …