Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Well-defined nickel and palladium precatalysts for cross-coupling

N Hazari, PR Melvin, MM Beromi - Nature Reviews Chemistry, 2017 - nature.com
Transition metal-catalysed cross-coupling is one of the most powerful synthetic methods and
has led to vast improvements in the synthesis of pharmaceuticals, agrochemicals and …

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

Recent advances in the synthesis of aryl nitrile compounds

G Yan, Y Zhang, J Wang - Advanced Synthesis & Catalysis, 2017 - Wiley Online Library
Aryl nitriles are widely found in natural products, pharmaceuticals, agrochemicals, dyes, and
herbicides. Moreover, because the cyano group can be easily converted into various …

Chalcogen-bridged coordination polymer for the photocatalytic activation of aryl halides

L Zeng, T Zhang, R Liu, W Tian, K Wu, J Zhu… - Nature …, 2023 - nature.com
The ability to deliver electrons is vital for dye-based photocatalysts. Conventionally, the
aromatic stacking-based charge-transfer complex increases photogenerated electron …

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

NJ Taylor, E Emer, S Preshlock… - Journal of the …, 2017 - ACS Publications
Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to
visualize, characterize and measure biological processes in the body. Despite recent …

Fast carbon isotope exchange of carboxylic acids enabled by organic photoredox catalysis

D Kong, M Munch, Q Qiqige, CJC Cooze… - Journal of the …, 2021 - ACS Publications
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange
of C (sp3) acids with labeled CO2. Substrates that are not compatible with transition-metal …

Palladium‐mediated arylation of lysine in unprotected peptides

HG Lee, G Lautrette, BL Pentelute… - Angewandte Chemie …, 2017 - Wiley Online Library
A mild method for the arylation of lysine in an unprotected peptide is presented. In the
presence of a preformed biarylphosphine‐supported palladium (II)–aryl complex and a …

Visualization of AMPA receptors in living human brain with positron emission tomography

T Miyazaki, W Nakajima, M Hatano, Y Shibata… - Nature medicine, 2020 - nature.com
Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-
methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric …

New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals

K Dahl, C Halldin, M Schou - Clinical and Translational Imaging, 2017 - Springer
Purpose This short review aims to cover the more recent and promising developments of
carbon-11 (11 C) labeling radiochemistry and its utility in the production of novel …