Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …

The neurotransmitter acetylcholine (ACh) regulates a diverse array of physiological
processes throughout the body. Despite its importance, cholinergic transmission in the …

G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

Signaling-biased ligands acting on G-protein-coupled receptors (GPCRs) differentially
activate heterotrimeric G proteins and β-arrestins. Although a wealth of structural knowledge …

G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their
spatial organization in plasma membrane (PM) domains is believed to encode signaling …

G protein-coupled receptors (GPCRs) comprise a large and diverse class of signal-
transducing receptors that undergo dynamic and isoform-specific membrane trafficking …

HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its
overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 …

Over the last several decades, an impressive array of advanced microscopic and analytical
tools, such as single-particle tracking and nanoscopic fluorescence correlation …