Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Delineating the association of age and cortical thickness in healthy individuals is critical
given the association of cortical thickness with cognition and behavior. Previous research …

Human cortical thickness and surface area are genetically independent, emerge through
different neurobiological events during development, and are sensitive to different clinical …

Neuroimaging studies examining the effects of aging and neuropsychiatric disorders on the
cerebral cortex have largely been based on measures of cortical volume. Given that cortical …

Background: Inflammation is linked to cognitive decline in midlife, but the neural basis for
this link is unclear. One possibility is that inflammation associates with adverse changes in …

Older adults exhibit global reductions in cortical surface area, but little is known about the
regional patterns of reductions or how these relate to other measures of brain structure. This …

Normal aging is accompanied by global as well as regional structural changes. While these
age-related changes in gray matter volume have been extensively studied, less has been …

Abstract The Open Access Series of Imaging Studies is a series of neuroimaging data sets
that are publicly available for study and analysis. The present MRI data set consists of a …

Imaging studies of cerebral volumes often adjust for factors such as age that may confound
between-subject comparisons. However the use of nuisance covariates in imaging studies is …