Cis-regulatory sequences in plants: their importance, discovery, and future challenges
The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …
function to coordinate responses to developmental and environmental cues is of paramount …
Molecular quantitative trait loci
Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …
genetics, as much of disease-associated variation is located in non-coding regions with …
Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells
B Khatri, KL Tessneer, A Rasmussen… - Nature …, 2022 - nature.com
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …
[HTML][HTML] Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers
More than 40% of patients with late-stage colorectal cancer (CRC) develop liver metastasis
(LM). Which immune cells play important roles in CRC-LM and contribute to the difference …
(LM). Which immune cells play important roles in CRC-LM and contribute to the difference …
Beyond knockouts: fine‐tuning regulation of gene expression in plants with CRISPR‐Cas‐based promoter editing
The CRISPR‐Cas‐based genome editing field in plants is expanding rapidly. Editing plant
promoters to obtain cis‐regulatory alleles with altered expression levels or patterns of target …
promoters to obtain cis‐regulatory alleles with altered expression levels or patterns of target …
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants
The impact of genetic variants on cells challenged in biologically relevant contexts has not
been fully explored. Here, we activated CD4+ T cells from 89 healthy donors and performed …
been fully explored. Here, we activated CD4+ T cells from 89 healthy donors and performed …
High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci
Chromatin organization and enhancer-promoter contacts establish unique spatiotemporal
gene expression patterns in distinct cell types. Non-coding genetic variants can influence …
gene expression patterns in distinct cell types. Non-coding genetic variants can influence …
Three-dimensional genome organization in immune cell fate and function
S Cuartero, G Stik, R Stadhouders - Nature Reviews Immunology, 2023 - nature.com
Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …
transcriptional programmes. Three-dimensional (3D) organization of the genome has …
Recent advances in understanding the genetic basis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …
CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling
Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic
chromatin remodeling enzyme, is essential for the development of organs. The mutation of …
chromatin remodeling enzyme, is essential for the development of organs. The mutation of …