Both structural and inflammatory cells are capable of secreting transforming growth factor
(TGF)‐β and expressing TGF‐β receptors. TGF‐β can induce multiple cellular responses …

Fibrosis is a medical condition characterized by an excessive deposition of extracellular
matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases …

Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to
asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly …

Chromosome 17q21 contains a cluster of genes including ORMDL3 and GSDMB, which
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …

BACKGROUND: Asthma is a common chronic inflammatory disease of the airways
characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid …

Rationale Gastroesophageal reflux (GER) is common in patients with various airway
diseases. Airway epithelial cells can release growth factors that promote fibroblast …

Mast cells are major effector cells of inflammation and there is strong evidence that mast
cells play a significant role in asthma pathophysiology. There is also a growing body of …

Airway wall remodeling is a hallmark of asthma, characterized by subepithelial thickening
and extracellular matrix (ECM) remodeling. Mechanical stress due to hyperresponsive …

Allergenic serine proteases are important in the pathogenesis of asthma. One of these, Pen
c 13, is the immunodominant allergen produced by Penicillium citrinum. Many serine …

Hypoxia occurs in a number of pathological states, such as pulmonary, hematological, and
cardiovascular disorders. In this study, we examined the molecular mechanism by which …