Objectives: Hypocapnia is used in the management of acute brain injury and may be life-
saving in specific circumstances, but it can produce neuronal ischemia and injury, potentially …

Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

Background Mesenchymal stromal cells (MSCs) demonstrate considerable promise in
preclinical acute respiratory distress syndrome models. We wished to determine the efficacy …

Introduction Tidal volume and plateau pressure minimisation are the standard components
of a protective lung ventilation strategy for patients with acute respiratory distress syndrome …

Rationale: Many authors have suggested that the mechanism by which atelectasis
contributes to injury is through the repetitive opening and closing of distal airways in lung …

Objective: We tested the hypothesis that hypercapnic acidosis is associated with reduced
mortality rate in patients with acute lung injury independent of changes in mechanical …

Though well described even in ancient writings, the acute respiratory distress syndrome
(ARDS) gained major medical attention with the availability of mechanical ventilation and …

The capacity of organisms to sense changes in the levels of internal and external gases and
to respond accordingly is central to a range of physiologic and pathophysiologic processes …

Elevated blood and tissue CO2, or hypercapnia, is common in severe lung disease. Patients
with hypercapnia often develop lung infections and have an increased risk of death …

ABSTRACT Background: Mesenchymal stromal cells (MSCs) have been demonstrated to
attenuate acute lung injury when delivered by intravenous or intratracheal routes. he authors …