Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Background No study has gathered evidence from all randomized clinical trials (RCT s) with
anti‐inflammatory drugs measuring antidepressant effects including a detailed assessment …

Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …

Despite considerable progress in pharmacotherapy over the past seven decades, many
mental disorders remain insufficiently treated. This situation is in part due to the limited …

Importance Several studies have reported antidepressant effects of anti-inflammatory
treatment; however, the results have been conflicting and detrimental adverse effects may …

Accumulating evidence supports an association between depression and inflammatory
processes, a connection that seems to be bidirectional. Clinical trials have indicated …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the
expression of genes responsible for energy metabolism, cellular development, and …

BACKGROUND: We conducted a meta-analysis of studies comparing cytokine
concentrations between patients with bipolar disorder (BD) and healthy control subjects …

Several nutrition, food and dietary compounds have been suggested to be involved in the
onset and maintenance of depressive disorders and in the severity of depressive symptoms …