Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

The recently-defined four molecular subgroups of medulloblastoma have required updating
of our understanding of in vitro models to include molecular classification and risk …

Human pluripotent stem cells (hPSCs), including human embryonic stem cells and human
induced pluripotent stem cells, are unique cell sources for disease modeling, drug discovery …

In this work, we describe the fabrication and working of a modular microsystem that
recapitulates the functions of the “Neurovascular Unit”. The microdevice comprised a vertical …

Embryonic stem cells need to maintain genomic integrity so that they can retain the ability to
differentiate into multiple cell types without propagating DNA errors. Previous studies have …

Neurogenesis in the adult mammalian nervous system is now well established in the
subventricular zone of the anterolateral ventricle and subgranular zone of the hippocampus …

Basal lamina is present in many stem cell niches, but we still have a poor understanding of
the role of this and other extracellular matrix (ECM) components. Here, we review current …

The first comprehensive single-source reference on the minipig, this accessible manual
provides a resource for research scientists on the potential and use of the minipig as a …

Down syndrome (DS) is caused by trisomy of chromosome 21 and is characterized by
mental retardation, seizures and premature Alzheimer's disease. To examine …