The glycosylation in SARS-CoV-2 and its receptor ACE2
Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …
[HTML][HTML] ACE2-independent alternative receptors for SARS-CoV-2
S Lim, M Zhang, TL Chang - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent
of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public …
of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public …
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
Plant-derived anti-human epidermal growth factor receptor 2 antibody suppresses trastuzumab-resistant breast cancer with enhanced nanoscale binding
C Park, K Kim, Y Kim, R Zhu, L Hain, H Seferovic… - ACS …, 2024 - ACS Publications
Traditional monoclonal antibodies such as Trastuzumab encounter limitations when treating
Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer, particularly in …
Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer, particularly in …
Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity
Q Yang, A Kelkar, A Sriram, R Hombu, TA Hughes… - Science …, 2022 - science.org
Functional and epidemiological data suggest that N-linked glycans on the SARS-CoV-2
Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to …
Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to …
[HTML][HTML] A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo
Summary" Pan-coronavirus" antivirals targeting conserved viral components can be
designed. Here, we show that the rationally engineered H84T-banana lectin (H84T …
designed. Here, we show that the rationally engineered H84T-banana lectin (H84T …
[HTML][HTML] Molecular simulations of complex carbohydrates and glycoconjugates
E Fadda - Current opinion in chemical biology, 2022 - Elsevier
Complex carbohydrates (glycans) are the most abundant and versatile biopolymers in
nature. The broad diversity of biochemical functions that carbohydrates cover is a direct …
nature. The broad diversity of biochemical functions that carbohydrates cover is a direct …
[HTML][HTML] Principles of SARS-CoV-2 glycosylation
The structure and post-translational processing of the SARS-CoV-2 spike glycoprotein (S) is
intimately associated with the function of the virus and of sterilising vaccines. The surface of …
intimately associated with the function of the virus and of sterilising vaccines. The surface of …
Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance
I Alves, Â Fernandes, B Santos‐Pereira… - FEBS …, 2022 - Wiley Online Library
Glycans are carbohydrates that are made by all organisms and covalently conjugated to
other biomolecules. Glycans cover the surface of both human cells and pathogens and are …
other biomolecules. Glycans cover the surface of both human cells and pathogens and are …
Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) extensively N-glycosylates
its spike proteins, which are necessary for host cell invasion and the target of both vaccines …
its spike proteins, which are necessary for host cell invasion and the target of both vaccines …