In humans, microbial cells (including bacteria, archaea, and fungi) greatly outnumber host
cells. Candida albicans is the most prevalent fungal species of the human microbiota; this …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

The fungal pathogen Candida albicans causes macrophage death and escapes, but the
molecular mechanisms remained unknown. Here we used live-cell imaging to monitor the …

Background Vaginal candidiasis is an important medical condition awaiting more effective
treatment. How Candida albicans causes this disease and survives antifungal treatment is …

The ability of Candida sp. cells to adhere to the mucosal surfaces of various host organs as
well as synthetic materials is an important pathogenicity feature of those fungi which …

Objectives Biofilm-related human infections have high mortality rates due to drug resistance.
Cohabitation of diverse microbes in polymicrobial biofilms is common and these infections …

Background Plant genes that provide a different response to a similar dehydration stress
illustrate the concept of transcriptional 'dehydration stress memory'. Pre-exposing a plant to …

In this work, we synthesized a series of indole derivatives to cope with the current increasing
fungal infections caused by drug-resistant Candida albicans. All compounds were evaluated …

Clinical use of antimicrobials faces great challenges from the emergence of multidrug-
resistant pathogens. The overexpression of drug efflux pumps is one of the major …

Biofilm formation is an important microbial strategy for fungal pathogens, such as Fusarium,
Aspergillus, and Candida, to establish keratitis in patients wearing soft contact lenses …