Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Predictive biomarkers of response are essential to effectively guide targeted cancer
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …

Pharmacological inhibition of the ataxia telangiectasia and Rad3-related protein
serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged as …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

Highlights•Genome sequencing has made personalized therapy the preferred cancer
therapeutic approach.•In the past decade, the relevance of targeting DDR kinases for cancer …

DNA replication stress (RS) causes genomic instability and vulnerability in cancer cells. To
counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling …

Combinations of ataxia telangiectasia-and Rad3-related kinase inhibitors (ATRis) and poly
(ADP-ribose) polymerase inhibitors (PARPis) synergistically kill tumor cells through …