Introduction In order to assess the significance of drug levels measured in intensive care
medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by
both pharmacokinetic and pharmacodynamic mechanisms. Enzymes induced by tobacco …

Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …

In order to assess the significance of drug levels measured in clinical and forensic toxicology
as well as for Therapeutic Drug Monitoring (TDM) it is essential that good collections of data …

Neuronal nicotinic receptors are ligand-gated ion channels of the central and peripheral
central nervous system that regulate synaptic activity from both pre-and postsynaptic sites …

The human cytochrome P450, CYP2B6, is involved in the metabolism of several
therapeutically important drugs and environmental or abused toxicants. In this study, we …

BACKGROUND:: Major depressive disorder (MDD) is a common psychiatric condition, with
6.6% of the adult population in the United States experiencing a major depressive episode …

Many psychiatric patients smoke, and are believed to be heavier smokers than those without
psychiatric disorders. Cigarette smoking is one of the environmental factors that contributes …

The purpose of this study was to establish bupropion (BUP) hydroxylation as a selective in
vitro marker of cytochrome P450 (CYP) 2B6 catalytic activity. Among a panel of 16 human …