Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

Urothelial carcinoma is a common malignancy that carries a poor prognosis when the
disease includes muscle invasion. Metastatic urothelial carcinoma is almost uniformly fatal …

Abstract Treatment of muscle invasive urothelial bladder carcinoma (BCa) remains a major
challenge. Comprehensive genomic profiling of tumors and identification of driver mutations …

Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …

Cancer cells usually display higher proliferation rates than normal cells. Some currently
used antitumor drugs, such as vinca alkaloids and taxanes, act by targeting microtubules …

AURKA is a serine/threonine kinase overexpressed in several cancers. Originally identified
as a protein with multifaceted roles during mitosis, improvements in quantitative microscopy …

Survival of patients with muscle-invasive bladder cancer is poor and new therapies are
needed. Currently, none of the targeted agents that are approved for cancer therapy have …

Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is
available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent …

Pancreatic cancer is the most aggressive cancer worldwide with poor response to current
therapeutics. Alisertib (ALS), a potent and selective Aurora kinase A inhibitor, exhibits potent …