Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced
morbidity and mortality associated with HIV-1. Initially there was hope that ART would be …

HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …

HIV-1 causes a chronic, incurable disease due to its persistence in CD4+ T cells that contain
replication-competent provirus, but exhibit little or no active viral gene expression and …

This paper is devoted to the multidisciplinary modelling of a pandemic initiated by an
aggressive virus, specifically the so-called SARS–CoV–2 Severe Acute Respiratory …

The latent reservoir for HIV-1 in resting memory CD4+ T cells is the major barrier to curing
HIV-1 infection. Studies of HIV-1 latency have focused on regulation of viral gene expression …

Biological circuits can be controlled by two general schemes: environmental sensing or
autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent …

The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected
patients. The partial success of reactivation therapies suggests that the genomic context of …

HIV-1 infection cannot be cured because the virus persists as integrated proviral DNA in
long-lived cells despite years of suppressive antiretroviral therapy (ART). In a previous …

HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …