Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …

Normal brain functioning relies on high aerobic energy production provided by
mitochondria. Failure to supply a sufficient amount of energy, seen in different brain …

Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies …

The Rubinstein-Taybi syndrome (RSTS) is a rare congenital developmental disorder
characterized by a typical facial dysmorphism, distal limb abnormalities, intellectual …

RAD21 (also known as KIAA0078, NXP1, HR21, Mcd1, Scc1, and hereafter called RAD21),
an essential gene, encodes a DNA double-strand break (DSB) repair protein that is …

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

Genomic information is encoded on long strands of DNA, which are folded into chromatin
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …

Abstract Cornelia de Lange Syndrome (CdLS) is a rare, dominantly inherited multisystem
developmental disorder characterized by highly variable manifestations of growth and …

Cohesin regulates gene expression through context-specific chromatin folding mechanisms
such as enhancer–promoter loo** and topologically associating domain (TAD) formation …