NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
30 years of NF-κB: a blossoming of relevance to human pathobiology
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that
time, it has been found to have a broad role in gene induction in diverse cellular responses …
time, it has been found to have a broad role in gene induction in diverse cellular responses …
The CBM-opathies—a rapidly expanding spectrum of human inborn errors of immunity caused by mutations in the CARD11-BCL10-MALT1 complex
The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …
Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome
The CARMA1–BCL10–MALT1 (CBM) signalosome is a central mediator of T cell receptor
and B cell receptor-induced NF-κB signaling that regulates multiple lymphocyte functions …
and B cell receptor-induced NF-κB signaling that regulates multiple lymphocyte functions …
Hyper-IgE syndrome, 2021 update
Y Minegishi - Allergology International, 2021 - Elsevier
Clinically and pathologically, the patients with hyper-IgE syndrome present similar skin
manifestations to common atopic dermatitis. The original hyper-IgE syndrome is …
manifestations to common atopic dermatitis. The original hyper-IgE syndrome is …
Monogenic adult-onset inborn errors of immunity
F Staels, T Collignon, A Betrains, M Gerbaux… - Frontiers in …, 2021 - frontiersin.org
Inborn errors of immunity (IEI) are a heterogenous group of disorders driven by genetic
defects that functionally impact the development and/or function of the innate and/or …
defects that functionally impact the development and/or function of the innate and/or …
Holding all the CARDs: how MALT1 controls CARMA/CARD-dependent signaling
M Juilland, M Thome - Frontiers in immunology, 2018 - frontiersin.org
The scaffold proteins CARMA1-3 (encoded by the genes CARD11,-14 and-10) and CARD9
play major roles in signaling downstream of receptors with immunoreceptor tyrosine …
play major roles in signaling downstream of receptors with immunoreceptor tyrosine …
Mechanisms of regulated and dysregulated CARD11 signaling in adaptive immunity and disease
JR Bedsaul, NM Carter, KE Deibel… - Frontiers in …, 2018 - frontiersin.org
CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte
activation during the adaptive immune response. Somatic mutations in CARD11 are …
activation during the adaptive immune response. Somatic mutations in CARD11 are …
Germline CBM-opathies: from immunodeficiency to atopy
Caspase recruitment domain (CARD) protein–B cell CLL/lymphoma 10 (BCL10)–MALT1
paracaspase (MALT1)[CBM] complexes are critical signaling adaptors that facilitate immune …
paracaspase (MALT1)[CBM] complexes are critical signaling adaptors that facilitate immune …