P-glycoprotein: from genomics to mechanism
Resistance to chemically different natural product anti-cancer drugs (multidrug resistance, or
MDR) results from decreased drug accumulation, resulting from expression of one or more …
MDR) results from decreased drug accumulation, resulting from expression of one or more …
HPMA copolymers: origins, early developments, present, and future
J Kopeček, P Kopečková - Advanced drug delivery reviews, 2010 - Elsevier
The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
MRP3, an organic anion transporter able to transport anti-cancer drugs
M Kool, M Van Der Linden, M de Haas… - Proceedings of the …, 1999 - National Acad Sciences
The human multidrug-resistance protein (MRP) gene family contains at least six members:
MRP1, encoding the multidrug-resistance protein; MRP2 or cMOAT, encoding the …
MRP1, encoding the multidrug-resistance protein; MRP2 or cMOAT, encoding the …
Microtubules, microtubule-interfering agents and apoptosis
Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …
Polymer–drug conjugates: Origins, progress to date and future directions
J Kopeček - Advanced drug delivery reviews, 2013 - Elsevier
This overview focuses on bioconjugates of water-soluble polymers with low molecular
weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the …
weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the …
Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia. A …
CP Leith, KJ Kopecky, IM Chen… - Blood, The Journal …, 1999 - ashpublications.org
Therapeutic resistance is a major obstacle in the treatment of acute myeloid leukemia (AML).
Such resistance has been associated with rapid drug efflux mediated by the multidrug …
Such resistance has been associated with rapid drug efflux mediated by the multidrug …
HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action
The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …
[PDF][PDF] Cellular mechanisms of multidrug resistance of tumor cells
AA Stavrovskaya - Biochemistry c/c of Biokhimiia, 2000 - researchgate.net
Multidrug resistance (MDR) is the protection of a tumor cell population against numerous
drugs differing in chemical structure and mechanisms of influence on the cells. MDR is one …
drugs differing in chemical structure and mechanisms of influence on the cells. MDR is one …
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
JD Schuetz, MC Connelly, D Sun, SG Paibir… - Nature medicine, 1999 - nature.com
Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral
DNA polymerases, are a common component of highly active anti-retroviral therapy …
DNA polymerases, are a common component of highly active anti-retroviral therapy …
[HTML][HTML] Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity
Y Xu, MA Villalona-Calero - Annals of oncology, 2002 - Elsevier
Camptothecins are broad-spectrum anticancer drugs that specifically target DNA
topoisomerase I (Topo I). The formation of a cleavable drug–Topo I–DNA complex results in …
topoisomerase I (Topo I). The formation of a cleavable drug–Topo I–DNA complex results in …