Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

Metabolic homeostasis operates differently in men and women. This sex asymmetry is the
result of evolutionary adaptations that enable women to resist loss of energy stores and …

Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

The available data suggest differences in the course of type 2 diabetes mellitus (T2DM)
between men and women, influenced by the distinguishing features of the sex. Glucagon …

The liver is often thought of as a single functional unit, but both its structural and functional
architecture make it highly multivalent and adaptable. In any given physiological situation …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

The central nervous system has long been thought to regulate insulin secretion, an essential
process in the maintenance of blood glucose levels. However, the anatomical and functional …

Multiple lines of evidence indicate that the male sex is a significant risk factor for severe
disease and mortality due to coronavirus disease 2019 (COVID-19). However, the precise …

Pancreatic islet transplantation efficacy for type 1 diabetes (T1D) management is limited by
hypoxia-related graft attrition and need for systemic immunosuppression. To overcome …

Objective Pancreatic β cells play a key role in maintaining glucose homeostasis; dysfunction
of this critical cell type causes type 2 diabetes (T2D). Emerging evidence points to sex …