Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Prevention, treatment and cure of HIV infection
The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …
has been marked by a series of remarkable successes. However, the efforts to develop a …
Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy
H Imamichi, RL Dewar… - Proceedings of the …, 2016 - National Acad Sciences
Despite years of plasma HIV-RNA levels< 40 copies per milliliter during combination
antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent …
antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent …
Defective HIV-1 proviruses produce viral proteins
H Imamichi, M Smith, JW Adelsberger… - Proceedings of the …, 2020 - National Acad Sciences
HIV-1 proviruses persist in the CD4+ T cells of HIV-infected individuals despite years of
combination antiretroviral therapy (cART) with suppression of HIV-1 RNA levels< 40 …
combination antiretroviral therapy (cART) with suppression of HIV-1 RNA levels< 40 …
Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient
There is intense interest in develo** curative interventions for HIV. How such a cure will
be quantified and defined is not known. We applied a series of measurements of HIV …
be quantified and defined is not known. We applied a series of measurements of HIV …
HIV and HLA class I: an evolving relationship
Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …
settings where natural immunity to the pathogen results in clearance in at least some …
[HTML][HTML] Laboratory testing for the diagnosis of HIV infection: updated recommendations
BM Branson, SM Owen, LG Wesolowski, B Bennett… - 2014 - stacks.cdc.gov
This document updates recommendations for HIV testing by laboratories in the United States
and offers approaches for reporting test results to persons ordering HIV tests and to public …
and offers approaches for reporting test results to persons ordering HIV tests and to public …
Unravelling the mechanisms of durable control of HIV-1
Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …