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Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents
Q Chen, B Yang, X Liu, XD Zhang, L Zhang… - Theranostics, 2022 - pmc.ncbi.nlm.nih.gov
The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …
sequence homology and functional overlap and co-operation, are emerging as critical …
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
PD Talukdar, U Chatterji - Signal transduction and targeted therapy, 2023 - nature.com
Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …
programs that necessitate intricate synergic interactions between transcription factors and …
Histone modifications in transcriptional regulation
SL Berger - Current opinion in genetics & development, 2002 - Elsevier
Covalent modifications of the amino termini of the core histones in nucleosomes have
important roles in gene regulation. Research in the past two years reveals these …
important roles in gene regulation. Research in the past two years reveals these …
[HTML][HTML] Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB
The nuclear function of the heterodimeric NF‐κB transcription factor is regulated in part
through reversible acetylation of its RelA subunit. We now demonstrate that the p300 and …
through reversible acetylation of its RelA subunit. We now demonstrate that the p300 and …
Epigenetics in the pathogenesis of diabetic nephropathy: Epigenetics in the pathogenesis of diabetic nephropathy
X Li, L Lu, W Hou, T Huang, X Chen… - Acta Biochimica et …, 2021 - pmc.ncbi.nlm.nih.gov
Diabetic nephropathy (DN), which is a common microvascular complication with a high
incidence in diabetic patients, greatly increases the mortality of patients. With further study …
incidence in diabetic patients, greatly increases the mortality of patients. With further study …
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
MG Guenther, ORR Barak, MA Lazar - Molecular and cellular …, 2001 - Taylor & Francis
Repression of gene transcription is linked to regulation of chromatin structure through
deacetylation of core histone amino-terminal tails. This action is mediated by histone …
deacetylation of core histone amino-terminal tails. This action is mediated by histone …
Transcription factor dimerization activates the p300 acetyltransferase
E Ortega, S Rengachari, Z Ibrahim, N Hoghoughi… - Nature, 2018 - nature.com
The transcriptional co-activator p300 is a histone acetyltransferase (HAT) that is typically
recruited to transcriptional enhancers and regulates gene expression by acetylating …
recruited to transcriptional enhancers and regulates gene expression by acetylating …
CBP and p300: HATs for different occasions
E Kalkhoven - Biochemical pharmacology, 2004 - Elsevier
The transcriptional coactivators CREB binding protein (CBP) and p300 are key regulators of
RNA polymerase II-mediated transcription. Genetic alterations in the genes encoding these …
RNA polymerase II-mediated transcription. Genetic alterations in the genes encoding these …
Transcription factors in liver development, differentiation, and regeneration
RH Costa, VV Kalinichenko, AXL Holterman… - Hepatology, 2003 - journals.lww.com
Transcriptional Activation. The liver performs essential functions in the body by uniquely
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and …
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and …
Regulating histone acetyltransferases and deacetylases
G Legube, D Trouche - EMBO reports, 2003 - embopress.org
Histone acetyltransferases and histone deacetylases regulate the acetylation of histones
and transcription factors, and in doing so have major roles in the control of cell fate. Many …
and transcription factors, and in doing so have major roles in the control of cell fate. Many …