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Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides
Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …
Biotechnological advances in the synthesis of modified chondroitin towards novel biomedical applications
Chondroitin sulfate (CS) is a well-known glycosaminoglycan present in a large variety of
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …
animal tissues, with an outstanding structural heterogeneity mainly related to molecular …
Imaging of Escherichia coli K5 and glycosaminoglycan precursors via targeted metabolic labeling of capsular polysaccharides in bacteria
YJ Wang, L Li, J Yu, HY Hu, ZX Liu, WJ Jiang, W Xu… - Science …, 2023 - science.org
The introduction of unnatural chemical moieties into glycosaminoglycans (GAGs) has
enormous potential to facilitate studies of the mechanism and application of these critical …
enormous potential to facilitate studies of the mechanism and application of these critical …
[HTML][HTML] Heterologous production of chondroitin
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …
Enhancing the expression of chondroitin 4-O-sulfotransferase for one-pot enzymatic synthesis of chondroitin sulfate A
Chondroitin sulfate (CS) stands as a pivotal compound in dietary supplements for
osteoarthritis treatment, propelling significant interest in the biotechnological pursuit of …
osteoarthritis treatment, propelling significant interest in the biotechnological pursuit of …
[HTML][HTML] Characterization of emergent Avibacterium paragallinarum strains and the protection conferred by infectious coryza vaccines against them in China
Y Xu, J Cheng, X Huang, M Xu, J Feng, C Liu, G Zhang - Poultry Science, 2019 - Elsevier
Infectious coryza (IC), an acute respiratory disease of chickens, is caused by Avibacterium
paragallinarum. Here, the current epidemiological status of IC was investigated in China …
paragallinarum. Here, the current epidemiological status of IC was investigated in China …
Cell-based assay approaches for glycosaminoglycan synthase high-throughput screening: development and applications
HY Hu, JQ Deng, YJ Wang, Y Li, XL Meng… - ACS Chemical …, 2023 - ACS Publications
Glycosaminoglycan synthases have immense potential in applications involving synthesis of
oligosaccharides, using enzymatic approaches and construction of cell factories that …
oligosaccharides, using enzymatic approaches and construction of cell factories that …
Microbial production and metabolic engineering of chondroitin and chondroitin sulfate
Several commercial uses and potential novel applications have recently been described for
chondroitin sulfate (CS). However, the currently applied animal extractive procedure has a …
chondroitin sulfate (CS). However, the currently applied animal extractive procedure has a …
Novel β1,4 N-acetylglucosaminyltransferase in de novo enzymatic synthesis of hyaluronic acid oligosaccharides
JY Sun, JQ Deng, RR Du, SY **n, YL Cao, Z Lu… - Applied Microbiology …, 2023 - Springer
The efficiency of de novo synthesis of hyaluronic acid (HA) using Pasteurella multocida
hyaluronate synthase (PmHAS) is limited by its low catalytic activity during the initial reaction …
hyaluronate synthase (PmHAS) is limited by its low catalytic activity during the initial reaction …
Identification of a novel glucuronyltransferase from Streptomyces chromofuscus ATCC 49982 for natural product glucuronidation
Glycosylation is an effective way to increase the polarity of natural products. UDP-
glucuronyltransferases (UGTs) are commonly observed and extensively studied in phase II …
glucuronyltransferases (UGTs) are commonly observed and extensively studied in phase II …