The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …

Patients with kidney failure are at increased risk of SARS-CoV-2 infection, making effective
vaccinations a critical need. It is not known how well mRNA vaccines induce B and plasma …

The development and use of antibacterial glycoconjugate vaccines have significantly
reduced the occurrence of potentially fatal childhood and adult diseases such as …

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tionskrankheiten des Patienten erreicht werden (sog. Herdenprotektion). Je nach Erreger …

Despite the availability of advances in molecular diagnostic testing for infectious disease,
there is still a need for tools that advance clinical care and public health. Current methods …

BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella
enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines …

Nearly all licensed vaccines have been developed to confer protection against infectious
diseases by stimulating the production of antibodies by B cells, but the nature of a successful …

Next‐generation sequencing was used to investigate the B‐cell receptor heavy chain
transcript repertoire of different B‐cell subsets (naive, marginal zone (MZ), immunoglobulin …

Background Bacterial surface glycans are assembled by glycosyltransferases (GTs) that
transfer sugar monomers to long-chained lipid carriers. Most bacteria employ the 55-carbon …

Streptococcus pneumoniae (S. pneumoniae, pneumococcus) is a major cause of morbidity
and mortality worldwide. Achieving long-term immunity against S. pneumoniae through …