Aging is characterized by a decline in tissue function, but the underlying changes at cellular
resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a …

Gene activity defines cell identity, drives intercellular communication, and underlies the
functioning of multicellular organisms. We present the single-cell resolution atlas of gene …

Motor neurons (MNs) constitute an ancient cell type targeted by multiple adult-onset
diseases. It is therefore important to define the molecular makeup of adult MNs in animal …

During aging, animals experience a decline in proteostasis activity, including loss of stress-
response activation, culminating in the accumulation of misfolded proteins and toxic …

Organismal aging involves functional declines in both somatic and reproductive tissues.
Multiple strategies have been discovered to extend lifespan across species. However, how …

Cellular senescence is acknowledged as a key contributor to organismal ageing and late‐
life disease. Though popular, the study of senescence in vitro can be complicated by the …

Profiling the transcriptomes of single cells without sacrificing spatial information is a major
goal of the field of spatial transcriptomics, but current technologies require tradeoffs between …

Aging and the age-associated decline of the proteome is determined in part through
neuronal control of evolutionarily conserved transcriptional effectors, which safeguard …

A comprehensive description of nervous system function, and sex dimorphism within, is
incomplete without clear assessment of the diversity of its component cell types, neurons …

Background Progress in aging research has been greatly accelerated in recent years due to
the development of new tools and techniques for single-cell analysis (Dulken et al., 2019; Li …