Functional importance of the D614G mutation in the SARS-CoV-2 spike protein
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus
which binds its cellular receptor angiotensin-converting enzyme 2 (ACE2) and enters hosts …
which binds its cellular receptor angiotensin-converting enzyme 2 (ACE2) and enters hosts …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
[HTML][HTML] D614G spike mutation increases SARS CoV-2 susceptibility to neutralization
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired
a D614G mutation early in the pandemic that confers greater infectivity and is now the …
a D614G mutation early in the pandemic that confers greater infectivity and is now the …
The SARS-CoV-2 Spike variant D614G favors an open conformational state
The COVID-19 global pandemic is an international health emergency. It is caused by the
SARS-CoV-2 virus, which binds with its trimeric Spike protein to the ACE2 receptor in the …
SARS-CoV-2 virus, which binds with its trimeric Spike protein to the ACE2 receptor in the …
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants
The SARS-CoV-2 Spike protein needs to be in an open-state conformation to interact with
ACE2 to initiate viral entry. We utilise coarse-grained normal mode analysis to model the …
ACE2 to initiate viral entry. We utilise coarse-grained normal mode analysis to model the …
SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact
The trimeric spike (S) glycoprotein, which protrudes from the SARS-CoV-2 viral envelope,
binds to human ACE2, initiated by at least one protomer's receptor binding domain (RBD) …
binds to human ACE2, initiated by at least one protomer's receptor binding domain (RBD) …
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity
The progression of the COVID-19 pandemic has generated numerous emerging variants of
SARS-CoV-2 on a global scale. These variants have gained evolutionary advantages …
SARS-CoV-2 on a global scale. These variants have gained evolutionary advantages …
Dynamic network modeling of allosteric interactions and communication pathways in the SARS-CoV-2 spike trimer mutants: Differential modulation of conformational …
The rapidly growing body of structural and biochemical studies of the SARS-CoV-2 spike
glycoprotein has revealed a variety of distinct functional states with radically different …
glycoprotein has revealed a variety of distinct functional states with radically different …
Heparin: A simplistic repurposing to prevent SARS-CoV-2 transmission in light of its in-vitro nanomolar efficacy
The world is currently facing a novel coronavirus (SARS-CoV-2) pandemic. The greatest
threat that is disrupting the normal functioning of society is the exceptionally high species …
threat that is disrupting the normal functioning of society is the exceptionally high species …
COVID‐19: emergence and mutational diversification of SARS‐CoV‐2
H Brüssow - Microbial Biotechnology, 2021 - Wiley Online Library
The origin of the SARS‐CoV‐2 virus is not yet defined, but a viral zoonosis from bats–with or
without an alternative animal as an intermediate host–is still the most likely hypothesis. The …
without an alternative animal as an intermediate host–is still the most likely hypothesis. The …