Cilia are microtubule-based organelles that project from the cell surface. In humans and
other vertebrates, possession of a single cilium structure enables an assortment of cellular …

Retinoic acid (RA) is a metabolite of vitamin A (retinol) that plays various roles in
development to influence differentiation, patterning, and organogenesis. RA also serves as …

Despite significant advances in understanding nephron segment patterning, many questions
remain about the underlying genes and signaling pathways that orchestrate renal progenitor …

Knowledge about the genetic pathways that control nephron development is essential for
better understanding the basis of congenital malformations of the kidney. The transcription …

Kidney disease is a devastating condition affecting millions of people worldwide, where over
100,000 patients in the United States alone remain waiting for a lifesaving organ transplant …

Cilia are essential for the ontogeny and function of many tissues, including the kidney. Here,
we report that transcription factor ERRγ ortholog estrogen related receptor gamma a (Esrrγa) …

The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane
that is responsible for regulating glycine levels and contributing one-carbon units to folate …

Cilia are microtubule-based organelles that function in a multitude of physiological contexts
to perform chemosensing, mechanosensing, and fluid propulsion. The process of …

Noise is prevalent in biology and has been widely quantified using snapshot measurements.
This static view obscures our understanding of dynamic noise properties and how these …

Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process
of blood filtration. Congenital malformation or damage to podocytes has dire consequences …