Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Synapses enable neurons to communicate with each other and are therefore a prerequisite
for normal brain function. Presynaptically, this communication requires energy and …

Mitochondria are unique organelles that are essential for a variety of cellular processes
including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis …

The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

During cell division, it is critical to properly partition functional sets of organelles to each
daughter cell. The partitioning of mitochondria shares some common features with that of …