This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …

Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …

Termination of protein synthesis occurs when a translating ribosome encounters one of
three universally conserved stop codons: UAA, UAG or UGA. Release factors recognize stop …

The efficient, site-specific introduction of unnatural amino acids into proteins in mammalian
cells is an outstanding challenge in realizing the potential of genetic code expansion …

Eukaryotic translation termination is triggered by peptide release factors eRF1 and eRF3.
Whereas eRF1 recognizes all three termination codons and induces hydrolysis of peptidyl …

Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-
site and requires two release factors (RFs), eRF1 and eRF3, which bind to the A-site as an …

Translation termination is an essential cellular process, which is also of therapeutic interest
for diseases that manifest from premature stop codons. In eukaryotes, translation termination …

Eukaryotic translation termination is mediated by two interacting release factors, eRF1 and
eRF3, which act cooperatively to ensure efficient stop codon recognition and fast …

Protein phosphorylation regulates diverse processes in eukaryotic cells. Strategies for
installing site-specific phosphorylation in target proteins in eukaryotic cells, through routes …

Background Members of the eukaryote/archaea specific eRF1 and eRF3 protein families
have central roles in translation termination. They are also central to various mRNA …