The kinetochore is a multiprotein complex that mediates the attachment of a eukaryotic
chromosome to the mitotic spindle. The protein composition of kinetochores is similar across …

Human centromeres are specified by a stably inherited epigenetic mark that maintains
centromere position and function through a two-step mechanism relying on self-templating …

Centromeres, the chromosomal loci where spindle fibers attach during cell division to
segregate chromosomes, are typically found within satellite arrays in plants and animals …

Faithful chromosome segregation during cell division depends on the centromere, a
complex DNA/protein structure that links chromosomes to spindle microtubules. This …

Background Tc1/mariner transposons are widespread DNA transposable elements (TEs)
that have made important contributions to the evolution of host genomic complexity in …

The centromere is a chromatin region that is required for accurate inheritance of eukaryotic
chromosomes during cell divisions. Among the different centromere-associated proteins …

Histones are a major component of chromatin, the nucleoprotein complex fundamental to
regulating transcription, facilitating cell division, and maintaining genome integrity in almost …

JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the
well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and …

Genomic instability (GI) in cancer facilitates cancer evolution and is an exploitable target for
therapy purposes. However, specific genes involved in cancer GI remain elusive. Causal …

Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular
complex that is essential for accurate chromosome segregation during mitosis. Anti …