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The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
Poly (ADP-ribosyl) ation by PARP1: reaction mechanism and regulatory proteins
EE Alemasova, OI Lavrik - Nucleic acids research, 2019 - academic.oup.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is posttranslational modification of proteins by
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …
The comings and goings of PARP-1 in response to DNA damage
JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …
Cisplatin in the era of PARP inhibitors and immunotherapy
Platinum compounds such as cisplatin, carboplatin and oxaliplatin are widely used in
chemotherapy. Cisplatin induces cytotoxic DNA damage that blocks DNA replication and …
chemotherapy. Cisplatin induces cytotoxic DNA damage that blocks DNA replication and …
New insights into the molecular and cellular functions of poly (ADP-ribose) and PARPs
Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …
[HTML][HTML] SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity
Emerging evidence indicates that the accretion of senescent cells is linked to metabolic
disorders. However, the underlying mechanisms and metabolic consequences of cellular …
disorders. However, the underlying mechanisms and metabolic consequences of cellular …
Coordination of DNA single strand break repair
R Abbotts, DM Wilson III - Free Radical Biology and Medicine, 2017 - Elsevier
The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …
changes are programmed, such as the formation of DNA double strand breaks during …
Structural basis for DNA damage–dependent poly (ADP-ribosyl) ation by human PARP-1
MF Langelier, JL Planck, S Roy, JM Pascal - Science, 2012 - science.org
Poly (ADP-ribose) polymerase–1 (PARP-1)(ADP, adenosine diphosphate) has a modular
domain architecture that couples DNA damage detection to poly (ADP-ribosyl) ation activity …
domain architecture that couples DNA damage detection to poly (ADP-ribosyl) ation activity …
PARP-1 activation requires local unfolding of an autoinhibitory domain
JM Dawicki-McKenna, MF Langelier, JE DeNizio… - Molecular cell, 2015 - cell.com
Summary Poly (ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational
modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks …
modification PAR from substrate NAD+ to regulate multiple cellular processes. DNA breaks …
Structural basis of detection and signaling of DNA single-strand breaks by human PARP-1
S Eustermann, WF Wu, MF Langelier, JC Yang… - Molecular cell, 2015 - cell.com
Summary Poly (ADP-ribose) polymerase 1 (PARP-1) is a key eukaryotic stress sensor that
responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic …
responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic …