Bone marrow (BM) acts as a dynamic organ within the bone cavity, responsible for
hematopoiesis, skeletal remodeling, and immune system control. Bone marrow adipose …

Obesity and obesogenic behaviors are positively associated with both monoclonal
gammopathy of unknown significance (MGUS) and multiple myeloma (MM). As the only …

Background Therapeutic resistance occurs in most patients with multiple myeloma (MM).
One of the key mechanisms for MM drug resistance comes from the interaction between MM …

Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein
multiple myeloma (MM) originates and resides. However, the nature of the interaction …

Bone metastasis is the major cause of death in breast cancer. The lack of effective treatment
suggests that disease mechanisms are still largely unknown. As a key component of the …

Obesity is often linked to malignancies including multiple myeloma, and the underlying
mechanisms remain elusive. Here we showed that acetyl-CoA synthetase 2 (ACSS2) may …

Background Multiple myeloma (MM) is still incurable and characterized by clonal expansion
of plasma cells in the bone marrow (BM). Therefore, effective therapeutic interventions must …

Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone
metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly …

Over the past decade, it has become apparent that metabolic reprogramming is a key event
in tumor progression. The tumor microenvironment (TME) is a source of metabolites for …

Background Aging‐associated osteoporosis is frequently seen in the elderly in clinic, but
efficient managements are limited because of unclear nosogenesis. The current study aims …