Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …
permeate ions across the cell membrane in response to changes in membrane potential …
[HTML][HTML] Single-particle cryo-EM at crystallographic resolution
Y Cheng - Cell, 2015 - cell.com
Until only a few years ago, single-particle electron cryo-microscopy (cryo-EM) was usually
not the first choice for many structural biologists due to its limited resolution in the range of …
not the first choice for many structural biologists due to its limited resolution in the range of …
A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis
A new method to estimate the trajectories of particle motion and the amount of cumulative
beam damage in electron cryo-microscopy (cryo-EM) single-particle analysis is presented …
beam damage in electron cryo-microscopy (cryo-EM) single-particle analysis is presented …
[HTML][HTML] Cryo-electron microscopy for structural analysis of dynamic biological macromolecules
Background Since the introduction of what became today's standard for cryo-embedding of
biological macromolecules at native conditions more than 30 years ago, techniques and …
biological macromolecules at native conditions more than 30 years ago, techniques and …
[HTML][HTML] An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology
Transmission electron microscopy (EM) is a versatile technique that can be used to image
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …
Quantification of gallium cryo-FIB milling damage in biological lamellae
Cryogenic electron microscopy (cryo-EM) can reveal the molecular details of biological
processes in their native, cellular environment at atomic resolution. However, few cells are …
processes in their native, cellular environment at atomic resolution. However, few cells are …
Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using Cryo-EM
Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …
present different challenges for structure determination. They are biologically important for …
Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
Although electron cryo-microscopy (cryo-EM) single-particle analysis has become an
important tool for structural biology of large and flexible macro-molecular assemblies, the …
important tool for structural biology of large and flexible macro-molecular assemblies, the …
Structures of respiratory supercomplex I+ III2 reveal functional and conformational crosstalk
The mitochondrial electron transport chain complexes are organized into supercomplexes
(SCs) of defined stoichiometry, which have been proposed to regulate electron flux via …
(SCs) of defined stoichiometry, which have been proposed to regulate electron flux via …
Atomic model for the dimeric FO region of mitochondrial ATP synthase
Mitochondrial adenosine triphosphate (ATP) synthase produces the majority of ATP in
eukaryotic cells, and its dimerization is necessary to create the inner membrane folds, or …
eukaryotic cells, and its dimerization is necessary to create the inner membrane folds, or …