[HTML][HTML] Mitochondria–lysosome crosstalk: from physiology to neurodegeneration
Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …
[HTML][HTML] Molecular neurobiology of mTOR
K Switon, K Kotulska, A Janusz-Kaminska… - Neuroscience, 2017 - Elsevier
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …
controls several important aspects of mammalian cell function. mTOR activity is modulated …
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …
mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression
Mitochondrial dysfunction elicits various stress responses in different model systems, but
how these responses relate to each other and contribute to mitochondrial disease has …
how these responses relate to each other and contribute to mitochondrial disease has …
Serine catabolism feeds NADH when respiration is impaired
NADH provides electrons for aerobic ATP production. In cells deprived of oxygen or with
impaired electron transport chain activity, NADH accumulation can be toxic. To minimize …
impaired electron transport chain activity, NADH accumulation can be toxic. To minimize …
[HTML][HTML] Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
Electron transport chain (ETC) dysfunction or hypoxia causes toxic NADH accumulation.
How cells regenerate NAD+ under such conditions remains elusive. Here, integrating …
How cells regenerate NAD+ under such conditions remains elusive. Here, integrating …
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome
Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and is
currently incurable. The lack of effective models hampers our understanding of the …
currently incurable. The lack of effective models hampers our understanding of the …
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin
JM Harder, C Guymer, JPM Wood… - Proceedings of the …, 2020 - National Acad Sciences
Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma,
the leading cause of irreversible blindness. Here, we used RNA-sequencing and …
the leading cause of irreversible blindness. Here, we used RNA-sequencing and …
Impaired mitochondrial dynamics and mitophagy in neuronal models of tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or
TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 …
TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 …
Mitochondrial dysfunction and neurodegeneration in lysosomal storage disorders
Lysosomal storage disorders (LSDs) are rare inherited debilitating and often fatal disorders.
Caused by mutations affecting lysosomal proteins, LSDs are characterized by the …
Caused by mutations affecting lysosomal proteins, LSDs are characterized by the …