BACKGROUND Biomolecular mechanisms are typically inferred from static structural
“snapshots” obtained by x-ray crystallography, nuclear magnetic resonance (NMR) …

In most organisms, ABC transporters constitute one of the largest families of membrane
proteins. In humans, their functions are diverse and underpin numerous key physiological …

Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …

Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to
determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However …

Substrate‐binding proteins (SBP s) play an important role in solute uptake and signal
transduction. In 2010, Berntsson et al. classified the 114 organism‐specific SBP structures …

A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

Feynman commented that “Everything that living things do can be understood in terms of the
jiggling and wiggling of atoms”. Proteins can jiggle and wiggle large structural elements …

Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal
into an electrical current as well as the direct sampling of bodily fluids. Here we show that …

Substrate-binding proteins (SBPs) are associated with ATP-binding cassette importers and
switch from an open to a closed conformation upon substrate binding, providing specificity …

Chromosome replication depends on efficient removal of nucleosomes by accessory factors
to ensure rapid access to genomic information. Here, we show this process requires …