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Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …
Animal models of neurodegenerative diseases
Animal models of adult-onset neurodegenerative diseases have enhanced the
understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease …
understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease …
Current state of Alzheimer's fluid biomarkers
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …
heterogeneous pathophysiology. The number of people living with AD is predicted to …
Amyloid-beta and tau protein beyond Alzheimer's disease
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …
play key roles in Alzheimer's disease pathogenesis and are considered the main …
The advent of Alzheimer treatments will change the trajectory of human aging
Slowing neurodegenerative disorders of late life has lagged behind progress on other
chronic diseases. But advances in two areas, biochemical pathology and human genetics …
chronic diseases. But advances in two areas, biochemical pathology and human genetics …
Role of tau protein in Alzheimer's disease: The prime pathological player
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
Rodent models for Alzheimer disease
Animal models are indispensable tools for Alzheimer disease (AD) research. Over the
course of more than two decades, an increasing number of complementary rodent models …
course of more than two decades, an increasing number of complementary rodent models …
Molecular pathogenesis of Alzheimer's disease: an update
Dementia is a chronic or progressive syndrome, characterized by impaired cognitive
capacity beyond what could be considered a consequence of normal aging. It affects the …
capacity beyond what could be considered a consequence of normal aging. It affects the …
Amyloid-beta: a crucial factor in Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …
[HTML][HTML] Disease-modifying therapies for Alzheimer's disease: more questions than answers
Scientific advances over the last four decades have steadily infused the Alzheimer's disease
(AD) field with great optimism that therapies targeting Aβ, amyloid, tau, and innate immune …
(AD) field with great optimism that therapies targeting Aβ, amyloid, tau, and innate immune …