Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases

L Recinella, G Orlando, C Ferrante… - Frontiers in …, 2020 - frontiersin.org
Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

[HTML][HTML] Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training

CK Roberts, AL Hevener, RJ Barnard - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Adipokines mediate inflammation and insulin resistance

H Kwon, JE Pessin - Frontiers in endocrinology, 2013 - frontiersin.org
For many years, adipose tissue was considered as an inert energy storage organ that
accumulates and stores triacylglycerols during energy excess and releases fatty acids in …

Cytokines and abnormal glucose and lipid metabolism

J Shi, J Fan, Q Su, Z Yang - Frontiers in endocrinology, 2019 - frontiersin.org
Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

The role of adipokines in chronic inflammation

P Mancuso - ImmunoTargets and therapy, 2016 - Taylor & Francis
Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

JB Funcke, PE Scherer - Journal of lipid research, 2019 - ASBMB
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Chemerin: a multifaceted adipokine involved in metabolic disorders

G Helfer, QF Wu - Journal of Endocrinology, 2018 - joe.bioscientifica.com
Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

Adipokines in nonalcoholic fatty liver disease

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2016 - Elsevier
Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …

Chemerin: at the crossroads of inflammation and obesity

MC Ernst, CJ Sinal - Trends in Endocrinology & Metabolism, 2010 - cell.com
Chemerin is a secreted protein with a complex but well-established role in immune function.
Parallel lines of investigation also support the notion that chemerin is a novel adipokine that …

Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue

F Li, Y Li, Y Duan, CAA Hu, Y Tang, Y Yin - Cytokine & growth factor …, 2017 - Elsevier
Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle
is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are …