Stem cells represent an attractive resource for cardiac regeneration. However, the survival
and function of transplanted stem cells is poor and remains a major challenge for the …

During cardiac development and morphogenesis, cardiac progenitor cells differentiate into
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …

BACKGROUND: Experiments in mammalian models of cardiac injury suggest that the
cardiomyocyte-specific overexpression of CCND2 (cyclin D2, in humans) improves recovery …

Background: The regenerative capacity of the heart after myocardial infarction is limited. Our
previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin …

Background Human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs)
exhibit the potential to repair the injured heart after myocardial infarction (MI) by promoting …

Myocardial regeneration in patients with cardiac damage is a long-sought goal of clinical
medicine. In animal species in which regeneration occurs spontaneously, as well as in …

Exosomes, as nanoscale extracellular vesicles (EVs), are secreted by all types of cells to
facilitate intercellular communication in living organisms. After being taken up by …

Background Cardiac repair remains a thorny issue for survivors of acute myocardial
infarction (AMI), due to the regenerative inertia of myocardial cells. Cell-free therapies, such …

Efficient generation of cardiomyocytes from human-induced pluripotent stem cells (hiPSCs)
is important for their application in basic and translational studies. Space microgravity can …

Heart failure (HF) is a life-threatening disorder and is treated by drug therapies and surgical
interventions such as heart transplantation and left ventricular assist device (LVAD) …