Microbiota and the social brain
BACKGROUND Increasingly, it is recognized that the microbes resident in the
gastrointestinal tract can influence brain physiology and behavior. Research has shown that …
gastrointestinal tract can influence brain physiology and behavior. Research has shown that …
Microbial modulation of cardiovascular disease
JM Brown, SL Hazen - Nature Reviews Microbiology, 2018 - nature.com
Although diet has long been known to contribute to the pathogenesis of cardiovascular
disease (CVD), research over the past decade has revealed an unexpected interplay …
disease (CVD), research over the past decade has revealed an unexpected interplay …
Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction
The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …
resistance and associated with several sequelae of metabolic syndrome in humans …
Trimethylamine N‐oxide promotes vascular inflammation through signaling of mitogen‐activated protein kinase and nuclear factor‐κB
Background The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been
demonstrated to contribute to atherosclerosis and is associated with coronary artery disease …
demonstrated to contribute to atherosclerosis and is associated with coronary artery disease …
The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases
JM Brown, SL Hazen - Annual review of medicine, 2015 - annualreviews.org
The human gastrointestinal tract is home to trillions of bacteria, which vastly outnumber host
cells in the body. Although generally overlooked in the field of endocrinology, gut microbial …
cells in the body. Although generally overlooked in the field of endocrinology, gut microbial …
The TMAO-generating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance
Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO)
have recently been linked to cardiovascular disease (CVD) risk. Here, we performed …
have recently been linked to cardiovascular disease (CVD) risk. Here, we performed …
The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue
Emerging evidence suggests that microbes resident in the human intestine represent a key
environmental factor contributing to obesity-associated disorders. Here, we demonstrate that …
environmental factor contributing to obesity-associated disorders. Here, we demonstrate that …
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
J Miao, AV Ling, PV Manthena, ME Gearing… - Nature …, 2015 - nature.com
Despite the well-documented association between insulin resistance and cardiovascular
disease, the key targets of insulin relevant to the development of cardiovascular disease are …
disease, the key targets of insulin relevant to the development of cardiovascular disease are …
[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
The participation of cortical amygdala in innate, odour-driven behaviour
Innate behaviours are observed in naive animals without prior learning or experience,
suggesting that the neural circuits that mediate these behaviours are genetically determined …
suggesting that the neural circuits that mediate these behaviours are genetically determined …