Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Addictive drugs hijack mechanisms of learning and memory that normally underlie
reinforcement of natural rewards and induce synaptic plasticity of glutamatergic transmission …

(S)-Glutamic acid (Glu), which is the main excitatory neurotransmitter in the central nervous
system (CNS), and other excitatory amino acids (EAAs) operate through four different …

The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at
human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non …

Kynurenic acid is a tryptophan metabolite provided with antagonist activity on ionotropic
glutamate and α7 nicotinic acetylcholine receptors. We noticed that in rats with a dialysis …

Rapid information transfer within the brain depends on chemical signalling between
neurons that is mediated primarily by glutamate and GABA (γ-aminobutyric acid), acting at …

Glutamate is the major excitatory neurotransmitter in the brain and plays a unique role in a
variety of central nervous system (CNS) functions. The discovery of the metabotropic …

Depression and anxiety represent a major problem. However, the current treatment of both
groups of diseases is not satisfactory. As the glutamatergic system may play an important …